Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12725748 | 0.83 | LRRK2 (0.64) | LRRK2JAK2MAPK10PTK2NTRK1 | |
| SCHEMBL1632941 | 0.78 | LRRK2 (0.54) | LRRK2JAK2MAPK10BTKPTK2 | |
| SCHEMBL1632509 | 0.78 | LRRK2 (0.56) | LRRK2JAK2MAPK10PTK2NTRK1 | |
| SCHEMBL1632952 | 0.78 | LRRK2 (0.54) | LRRK2JAK2MAPK10PTK2NTRK1 | |
| SCHEMBL1634301 | 0.77 | LRRK2 (0.55) | LRRK2JAK2MAPK10PTK2NTRK1 | |
| SCHEMBL1633387 | 0.77 | LRRK2 (0.54) | LRRK2JAK2MAPK10PTK2 | |
| SCHEMBL4667878 | 0.77 | LRRK2 (0.54) | LRRK2JAK2MAPK10BTKPTK2 | |
| SCHEMBL1633422 | 0.73 | LRRK2 (0.59) | LRRK2JAK2MAPK10PTK2NTRK1 | |
| SCHEMBL12724719 | 0.73 | LRRK2 (0.54) | LRRK2JAK2MAPK10PTK2NTRK1 | |
| SCHEMBL17431968 | 0.72 | LRRK2 (1.00) | LRRK2JAK2PTK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |