Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.54 |
| ▸ | JAK1 | P23458 | 3/20 | 0.54 |
| ▸ | TYK2 | P29597 | 3/20 | 0.54 |
| ▸ | JAK3 | P52333 | 3/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 8/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 10/20 | 0.43 |
| ▸ | CCND1 | P24385 | 10/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.43 |
| ▸ | CDK1 | P06493 | 6/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633164 | 0.92 | JAK2 (0.54) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1632878 | 0.91 | JAK2 (0.53) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633043 | 0.90 | JAK2 (0.55) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1634187 | 0.90 | JAK2 (0.57) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1632549 | 0.89 | JAK2 (0.54) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL12724803 | 0.89 | JAK1 (0.57) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633815 | 0.87 | JAK2 (0.54) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1634198 | 0.87 | JAK2 (0.52) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1632641 | 0.86 | JAK2 (0.60) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1631022 | 0.86 | JAK2 (0.54) | JAK2JAK1TYK2JAK3TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |