Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.37 |
| ▸ | FASN | P49327 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17765375 | 0.92 | HDAC3 (0.41) | HDAC2HDAC3RAF1BRAFHDAC1 | |
| SCHEMBL16339537 | 0.92 | IKBKE (0.41) | HDAC2HDAC3RAF1BRAFIRAK4 | |
| SCHEMBL16339631 | 0.85 | HDAC2 (0.51) | HDAC2HDAC3FASNHDAC1HDAC10 | |
| Hydrochloric Acid SCHEMBL17765374 | 0.84 | HDAC2 (0.50) | HDAC2HDAC3FASNHDAC1HDAC10 | |
| SCHEMBL16339353 | 0.83 | IKBKE (0.39) | RAF1BRAFIRAK4FSCN1IKBKE | |
| SCHEMBL16339445 | 0.81 | LCK (0.41) | IRAK4FSCN1IKBKETBK1MAPK7 | |
| SCHEMBL24032909 | 0.81 | MAPK7 (0.44) | HDAC2HDAC3RAF1BRAFHDAC6 | |
| SCHEMBL24033086 | 0.80 | HDAC3 (0.52) | HDAC2HDAC3HDAC1MAPK7 | |
| SCHEMBL16340026 | 0.79 | IRAK4 (0.38) | RAF1BRAFIRAK4FSCN1IKBKE | |
| SCHEMBL25105108 | 0.79 | IRAK4 (0.37) | RAF1BRAFIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013345-A2 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | F. Hoffmann-La Roche AG (CH) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014209841-A2 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | F. HOFFMANN-LA ROCHE AG (CH) | 2014-12-31 | — | — | WO | disclosed |