Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 4/20 | 0.69 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | JUN | P05412 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13498339 | 0.90 | MAPK10 (0.72) | MAPK10NTRK1JAK2LRRK2JUN | |
| SCHEMBL1633488 | 0.88 | MAPK10 (0.56) | MAPK10NTRK1JAK2JUNMAPK8 | |
| SCHEMBL1631590 | 0.86 | MAPK10 (0.50) | MAPK10JUNMAPK8CDK2CCNE1 | |
| SCHEMBL1632887 | 0.84 | MAPK10 (0.48) | MAPK10JUNMAPK8FGFR2 | |
| SCHEMBL1632822 | 0.84 | MAPK10 (0.49) | MAPK10JAK2JUNMAPK8FGFR2 | |
| SCHEMBL1634890 | 0.84 | MAPK10 (0.47) | MAPK10JAK2JUNMAPK8CDK1 | |
| SCHEMBL1632441 | 0.84 | MAPK10 (0.48) | MAPK10JAK2JUNMAPK8FGFR2 | |
| SCHEMBL1634397 | 0.84 | MAPK10 (0.59) | MAPK10JAK2JUNMAPK8FGFR2 | |
| SCHEMBL1633503 | 0.84 | MAPK10 (0.47) | MAPK10JAK2JUNMAPK8CDK1 | |
| SCHEMBL1633121 | 0.83 | MAPK10 (0.52) | MAPK10NTRK1JAK2JUNMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |