Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | JUN | P05412 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633192 | 0.90 | JAK2 (0.55) | MAPK10JAK2BRD4JUNMAPK8 | |
| SCHEMBL1633314 | 0.89 | MAPK10 (0.49) | MAPK10JAK2BRD4JUNMAPK8 | |
| SCHEMBL1633868 | 0.87 | MAPK10 (0.57) | MAPK10JAK2JUNMAPK8CA2 | |
| SCHEMBL12724257 | 0.86 | MAPK10 (0.46) | MAPK10JAK2BRD4JUNMAPK8 | |
| SCHEMBL13498291 | 0.85 | MAPK10 (0.46) | MAPK10JAK2BRD4JUNMAPK8 | |
| SCHEMBL1635106 | 0.82 | FGFR4 (0.47) | MAPK10JAK2BRD4JUNMAPK8 | |
| SCHEMBL1632806 | 0.82 | FGFR4 (0.47) | MAPK10JAK2BRD4JUNMAPK8 | |
| SCHEMBL1632803 | 0.82 | FGFR4 (0.47) | MAPK10JAK2BRD4JUNMAPK8 | |
| SCHEMBL1633022 | 0.81 | MAPK10 (0.44) | MAPK10JAK2BRD4JUNMAPK8 | |
| SCHEMBL1632115 | 0.79 | JAK2 (0.66) | JAK2BRD4EGFRAURKACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |