Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.36 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.36 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16339445 | 0.97 | LCK (0.41) | LCKJAK3BTKTNK2MAPT | |
| SCHEMBL16339353 | 0.95 | IKBKE (0.39) | LCKMAPTKMT2APTK6AURKB | |
| SCHEMBL16340026 | 0.88 | IRAK4 (0.38) | IRAK4USP28FSCN1IKBKETBK1 | |
| SCHEMBL16339537 | 0.86 | IKBKE (0.41) | PTK6AURKBIRAK4FSCN1IKBKE | |
| SCHEMBL16339370 | 0.85 | HDAC1 (0.42) | USP28USP25HTTBRPF1ZAP70 | |
| SCHEMBL16339136 | 0.83 | IDH1 (0.37) | LCKJAK3BTKTNK2NPC1 | |
| SCHEMBL25418681 | 0.82 | MAPT (0.45) | LCKJAK3BTKTNK2MAPT | |
| SCHEMBL30422856 | 0.82 | MAPT (0.45) | LCKJAK3BTKTNK2MAPT | |
| Hydrochloric Acid SCHEMBL30422569 | 0.82 | MAPT (0.45) | LCKJAK3BTKTNK2MAPT | |
| SCHEMBL25439487 | 0.80 | BCL6 (0.41) | MAPTPTK6AURKBPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013345-A2 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | F. Hoffmann-La Roche AG (CH) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014209841-A2 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | F. HOFFMANN-LA ROCHE AG (CH) | 2014-12-31 | — | — | WO | disclosed |