Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 7/20 | 0.55 |
| ▸ | ORAI1 | Q96D31 | 7/20 | 0.55 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.37 |
| ▸ | IL2 | P60568 | 5/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.31 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16381661 | 0.85 | STIM1 (0.52) | STIM1ORAI1ORAI2IL2NPY5R | |
| SCHEMBL14225923 | 0.80 | STIM1 (0.74) | STIM1ORAI1ORAI2IL2 | |
| SCHEMBL16334639 | 0.76 | STIM1 (0.55) | STIM1ORAI1ORAI2IL2 | |
| SCHEMBL17746839 | 0.73 | STIM1 (0.42) | STIM1ORAI1NPY5R | |
| SCHEMBL17746853 | 0.72 | STIM1 (0.64) | STIM1ORAI1IL2 | |
| SCHEMBL14225981 | 0.71 | STIM1 (0.50) | STIM1ORAI1ORAI2CCNT1 | |
| SCHEMBL14226017 | 0.71 | STIM1 (1.00) | STIM1ORAI1ORAI2IL2 | |
| SCHEMBL14239033 | 0.71 | STIM1 (0.64) | STIM1ORAI1ORAI2IL2 | |
| SCHEMBL16334771 | 0.71 | STIM1 (0.53) | STIM1ORAI1ORAI2IL2 | |
| SCHEMBL14225961 | 0.71 | STIM1 (0.58) | STIM1ORAI1IL2CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013810-A1 | CHROMANE AND CHROMENE DERIVATIVES AND THEIR USE AS CRAC MODULATORS | Lupin Limited (IN) | 2016-05-04 | — | — | EP | claimed |
| WO-2014207648-A1 | CHROMANE AND CHROMENE DERIVATIVES AND THEIR USE AS CRAC MODULATORS | LUPIN LIMITED (IN) | 2014-12-31 | — | — | WO | claimed |