Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.60 |
| ▸ | CA2 | P00918 | 5/20 | 0.60 |
| ▸ | CA9 | Q16790 | 5/20 | 0.60 |
| ▸ | IKBKB | O14920 | 8/20 | 0.57 |
| ▸ | DKK1 | O94907 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CCNH | P51946 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | STK4 | Q13043 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633446 | 0.90 | IKBKB (0.56) | CA1CA2CA9IKBKBCA12 | |
| SCHEMBL1633814 | 0.88 | EGFR (0.55) | CA1CA2CA9IKBKBDKK1 | |
| SCHEMBL1632432 | 0.87 | CYP1A2 (0.48) | CA1CA2CA9IKBKBDKK1 | |
| SCHEMBL1634190 | 0.87 | IKBKB (0.53) | CA1CA2CA9IKBKBDKK1 | |
| SCHEMBL1633821 | 0.87 | STK4 (0.52) | CA1CA2CA9IKBKBCCNT1 | |
| SCHEMBL1633962 | 0.86 | IKBKB (0.51) | CA1CA2CA9IKBKBDKK1 | |
| SCHEMBL1633413 | 0.86 | CA1 (0.47) | CA1CA2CA9IKBKBDKK1 | |
| SCHEMBL1633262 | 0.84 | IKBKB (0.49) | CA1CA2CA9IKBKBDKK1 | |
| SCHEMBL1632825 | 0.84 | IKBKB (0.48) | CA1CA2CA9IKBKBDKK1 | |
| SCHEMBL1631365 | 0.82 | IKBKB (0.46) | CA1CA2CA9IKBKBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |