Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632419 | 0.90 | IGF1R (0.44) | IGF1RMERTKAXLTYRO3POLB | |
| SCHEMBL1634287 | 0.87 | IGF1R (0.47) | IGF1RMERTKAXLTYRO3TSHR | |
| SCHEMBL1632322 | 0.87 | HRH3 (0.47) | IGF1RMERTKAXLTYRO3TSHR | |
| SCHEMBL1633516 | 0.86 | IGF1R (0.49) | IGF1RMERTKAXLTYRO3CDK2 | |
| SCHEMBL1634653 | 0.83 | MERTK (0.48) | IGF1RMERTKAXLTYRO3 | |
| SCHEMBL1633172 | 0.80 | KDM4E (0.59) | IGF1RMERTKAXLTYRO3TSHR | |
| SCHEMBL1632893 | 0.79 | MERTK (0.49) | IGF1RMERTKAXLTYRO3TSHR | |
| SCHEMBL1632410 | 0.75 | MERTK (0.52) | IGF1RMERTKAXLTYRO3CDK2 | |
| SCHEMBL1633106 | 0.75 | IKBKB (0.49) | CDK2CCNA2CCNA1IKBKBCCNE1 | |
| SCHEMBL1632946 | 0.75 | IKBKB (0.45) | CDK2CCNT1CCNA2CDK9CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |