Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30297449 | 0.79 | EPHX2 (0.30) | EPHX2 | |
| SCHEMBL29033090 | 0.79 | EPHX2 (0.33) | EPHX2PDE2A | |
| SCHEMBL18130015 | 0.76 | EPHX2 (0.37) | EPHX2ERN1PDE2AMAOAMAOB | |
| SCHEMBL128470 | 0.74 | ERN1 (0.32) | ERN1MEN1LMNAMAPTHPGD | |
| SCHEMBL21487604 | 0.74 | PDE2A (0.33) | EPHX2ERN1PDE2AMAOAMAOB | |
| SCHEMBL25310703 | 0.73 | KDM4E (0.34) | EPHX2MAOAMAOBLMNAMAPT | |
| SCHEMBL16345588 | 0.71 | NOTUM (0.35) | MEN1LMNAMAPTHTTKMT2A | |
| SCHEMBL31418229 | 0.69 | EPHX2 (0.38) | EPHX2PDE2AMAOAMAOBMEN1 | |
| SCHEMBL263399 | 0.69 | EPHX2 (0.38) | EPHX2PDE2AMAOAMAOBMEN1 | |
| SCHEMBL20309114 | 0.69 | TRPV1 (0.32) | EPHX2SLC1A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016946-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics, Inc. (US) | 2016-05-11 | — | — | EP | disclosed |
| WO-2015003166-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2015-01-08 | — | — | WO | disclosed |