Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | JAK1 | P23458 | 2/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 7/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 3/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 5/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633545 | 0.91 | JAK2 (0.65) | TNIKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1633530 | 0.89 | JAK2 (0.58) | TNIKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1632062 | 0.88 | JAK2 (0.52) | TNIKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1632939 | 0.88 | JAK2 (0.51) | TNIKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1634722 | 0.87 | JAK2 (0.54) | TNIKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1632781 | 0.87 | JAK2 (0.58) | TNIKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1632785 | 0.87 | JAK2 (0.58) | TNIKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1634422 | 0.87 | JAK2 (0.58) | TNIKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1632811 | 0.86 | JAK2 (0.54) | TNIKJAK2JAK1TYK2JAK3 | |
| SCHEMBL1631022 | 0.86 | JAK2 (0.54) | TNIKJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |