Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CETP | P11597 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | UBE2N | P61088 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7589302 | 1.00 | TSHR (0.62) | TSHRLMNAACE2CYP2D6SPHK1 | |
| SCHEMBL1646376 | 1.00 | TSHR (0.62) | TSHRLMNAACE2CYP2D6SPHK1 | |
| SCHEMBL7681938 | 1.00 | TSHR (0.62) | TSHRLMNAACE2CYP2D6SPHK1 | |
| SCHEMBL3726885 | 1.00 | TSHR (0.62) | TSHRLMNAACE2CYP2D6SPHK1 | |
| SCHEMBL20610571 | 1.00 | TSHR (0.62) | TSHRLMNAACE2CYP2D6SPHK1 | |
| SCHEMBL704286 | 1.00 | TSHR (0.62) | TSHRLMNAACE2CYP2D6SPHK1 | |
| SCHEMBL10621906 | 1.00 | TSHR (0.62) | TSHRLMNAACE2CYP2D6SPHK1 | |
| SCHEMBL976392 | 1.00 | TSHR (0.62) | TSHRLMNAACE2CYP2D6SPHK1 | |
| SCHEMBL18265498 | 1.00 | TSHR (0.62) | TSHRLMNAACE2CYP2D6SPHK1 | |
| SCHEMBL19994227 | 1.00 | TSHR (0.62) | TSHRLMNAACE2CYP2D6SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7833993-B2 | Immunomodulatory compounds and methods of use thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-11-16 | — | — | US | disclosed |
| US-7560584-B2 | Immunomodulatory compounds and methods of use thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-07-14 | — | — | US | disclosed |