Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TYMP | P19971 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
| ▸ | NT5E | P21589 | 2/20 | 0.32 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.32 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.32 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.32 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.32 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.30 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14066268 | 0.92 | POLB (0.41) | POLBTYMPABL1RIN1NT5E | |
| SCHEMBL12197508 | 0.91 | POLB (0.43) | POLBTYMPABL1RIN1NT5E | |
| SCHEMBL874315 | 0.90 | POLB (0.49) | POLBTYMPABL1RIN1NT5E | |
| SCHEMBL12197787 | 0.87 | POLB (0.40) | POLBTYMPABL1RIN1NT5E | |
| SCHEMBL837389 | 0.87 | POLB (0.40) | POLBTYMPABL1RIN1NT5E | |
| SCHEMBL10095143 | 0.86 | POLB (0.39) | POLBTYMPABL1RIN1NT5E | |
| SCHEMBL10095196 | 0.86 | POLB (0.39) | POLBTYMPABL1RIN1NT5E | |
| SCHEMBL13036642 | 0.85 | TYMP (0.38) | POLBTYMPP2RY6SLC6A1SLC6A11 | |
| SCHEMBL838369 | 0.81 | POLB (0.38) | POLBABL1RIN1 | |
| SCHEMBL14066269 | 0.81 | POLB (0.50) | POLBTYMPABL1RIN1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888367-B2 | reverse transcriptase mutants which allow an obligate chain terminating nucleoside- or nucleotide phosphate to be excised from the nascent DNA strand by ATP- or pyrophosphate-mediated excision | MEDIVIR AB (SE) | 2011-02-15 | — | — | US | disclosed |