Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 8/20 | 0.62 |
| ▸ | CBLB | Q13191 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL944923 | 0.92 | MAP3K5 (0.61) | MAP3K5CBLBLMNAGAACLK1 | |
| SCHEMBL943985 | 0.92 | MAP3K5 (0.58) | MAP3K5CBLBLMNAGAAWNT3A | |
| SCHEMBL15423230 | 0.91 | MAP3K5 (0.59) | MAP3K5CBLBLMNAGAACLK1 | |
| SCHEMBL946695 | 0.90 | MAP3K5 (0.58) | MAP3K5CBLBLMNAGAAWNT3A | |
| SCHEMBL14553730 | 0.90 | MAP3K5 (0.62) | MAP3K5CBLBLMNAGAACCNC | |
| SCHEMBL945190 | 0.90 | MAP3K5 (0.63) | MAP3K5CBLBLMNAGAAALDH1A1 | |
| SCHEMBL945922 | 0.90 | MAP3K5 (0.66) | MAP3K5CBLBLMNAGAACCNC | |
| SCHEMBL945552 | 0.90 | MAP3K5 (0.63) | MAP3K5CBLBLMNAGAACLK1 | |
| SCHEMBL943988 | 0.89 | MAP3K5 (0.69) | MAP3K5CBLBLMNAGAACCNC | |
| SCHEMBL944241 | 0.89 | MAP3K5 (0.62) | MAP3K5CBLBLMNAGAACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3363797-B1 | ORAL DOSAGE FORM OF APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2020-12-02 | — | — | EP | claimed |
| EP-2933252-B1 | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES INC (US) | 2018-01-03 | — | — | EP | claimed |
| EP-2454250-B1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2015-01-14 | — | — | EP | claimed |