Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.68 |
| ▸ | GPR52 | Q9Y2T5 | 5/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15444480 | 0.95 | SLC34A2 (0.70) | SLC34A2GPR52PSEN1PSEN2APH1B | |
| SCHEMBL10290125 | 0.95 | SLC34A2 (0.70) | SLC34A2GPR52PSEN1PSEN2APH1B | |
| SCHEMBL15432903 | 0.95 | SLC34A2 (0.70) | SLC34A2GPR52PSEN1PSEN2APH1B | |
| SCHEMBL16365458 | 0.93 | SLC34A2 (0.67) | SLC34A2GPR52PSEN1PSEN2APH1B | |
| SCHEMBL16808325 | 0.93 | SLC34A2 (0.79) | SLC34A2GPR52PSEN1PSEN2APH1B | |
| SCHEMBL6001902 | 0.92 | SLC34A2 (0.73) | SLC34A2GPR52PSEN1PSEN2APH1B | |
| SCHEMBL16355245 | 0.92 | SLC34A2 (0.73) | SLC34A2GPR52PSEN1PSEN2APH1B | |
| SCHEMBL6000395 | 0.92 | SLC34A2 (0.72) | SLC34A2GPR52PSEN1PSEN2APH1B | |
| SCHEMBL46541 | 0.91 | SLC34A2 (0.67) | SLC34A2GPR52PSEN1PSEN2APH1B | |
| SCHEMBL46542 | 0.91 | SLC34A2 (0.71) | SLC34A2GPR52PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916569-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-8916569-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2014-12-23 | — | — | US | disclosed |