Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 11/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764773 | 0.90 | TP53 (0.63) | MAPTTP53SMN1; SMN2HTR2AHTR2C | |
| SCHEMBL8403219 | 0.84 | MAPT (0.67) | MAPTTP53SMN1; SMN2KIF11HTR2A | |
| SCHEMBL764816 | 0.82 | TP53 (0.49) | MAPTTP53KIF11HTR2AHTR2C | |
| SCHEMBL8403217 | 0.81 | TP53 (0.60) | MAPTTP53SMN1; SMN2KIF11ABCB1 | |
| SCHEMBL763499 | 0.81 | TP53 (0.61) | MAPTTP53SMN1; SMN2HTR2AHTR2C | |
| SCHEMBL8403288 | 0.80 | TP53 (0.61) | MAPTTP53SMN1; SMN2KIF11HTR2A | |
| SCHEMBL8404164 | 0.80 | TP53 (0.60) | MAPTTP53SMN1; SMN2KIF11ABCB1 | |
| SCHEMBL8402844 | 0.79 | TP53 (0.79) | MAPTTP53SMN1; SMN2ABCB1ABCG2 | |
| SCHEMBL13049857 | 0.79 | TP53 (0.57) | MAPTTP53SMN1; SMN2KIF11HTR2A | |
| SCHEMBL8404177 | 0.79 | TP53 (0.59) | MAPTTP53SMN1; SMN2KIF11ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008127714-A1 | ADMINISTRATION OF CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |