Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.78 |
| ▸ | NPC1 | O15118 | 1/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21098369 | 0.93 | SMN1; SMN2 (0.89) | SMN1; SMN2NPC1POLBALDH1A1MAPT | |
| SCHEMBL4484066 | 0.88 | SMN1; SMN2 (0.80) | SMN1; SMN2NPC1POLBALDH1A1MAPT | |
| SCHEMBL4770380 | 0.87 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1POLBALDH1A1MAPT | |
| SCHEMBL13211944 | 0.87 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1POLBALDH1A1MAPT | |
| SCHEMBL6571604 | 0.87 | SMN1; SMN2 (0.84) | SMN1; SMN2NPC1POLBALDH1A1MAPT | |
| SCHEMBL95881 | 0.87 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1POLBALDH1A1MAPT | |
| SCHEMBL5257694 | 0.87 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1POLBALDH1A1MAPT | |
| SCHEMBL1775216 | 0.86 | SMN1; SMN2 (0.82) | SMN1; SMN2NPC1POLBALDH1A1MAPT | |
| SCHEMBL13762099 | 0.85 | MEN1 (0.78) | SMN1; SMN2NPC1POLBALDH1A1MAPT | |
| SCHEMBL13766445 | 0.85 | SMN1; SMN2 (0.74) | SMN1; SMN2NPC1POLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008127715-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |