Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.53 |
| ▸ | PDE2A | O00408 | 2/20 | 0.53 |
| ▸ | PDE8A | O60658 | 2/20 | 0.53 |
| ▸ | PDE5A | O76074 | 2/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.53 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.53 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.53 |
| ▸ | PDE9A | O76083 | 1/20 | 0.53 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15479041 | 0.83 | PDE4A (0.73) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL16360148 | 0.83 | PDE4A (0.54) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL15238037 | 0.77 | PDE4A (0.51) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL774823 | 0.76 | PDE4A (0.69) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL15238030 | 0.75 | PDE4A (0.74) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL2511191 | 0.74 | PDE4A (0.60) | PDE4APDE1A | |
| SCHEMBL16435878 | 0.74 | PDE4A (0.52) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL16359932 | 0.73 | PDE4A (0.65) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL15479047 | 0.73 | PDE4A (0.63) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL23082965 | 0.72 | PDE4A (0.63) | PDE4APDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132127-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |