Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 8/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2802673 | 0.93 | FGFR1 (0.43) | FGFR1FGFR2CSNK2A1EGFR | |
| SCHEMBL2802954 | 0.87 | FGFR1 (0.54) | FGFR1FGFR2MALT1S100A4EGFR | |
| SCHEMBL2804612 | 0.86 | FGFR1 (0.53) | FGFR1FGFR2MALT1S100A4 | |
| SCHEMBL2803907 | 0.86 | FGFR1 (0.53) | FGFR1FGFR2MALT1S100A4 | |
| SCHEMBL2806026 | 0.85 | CHRNA7 (0.47) | FGFR1FGFR2 | |
| SCHEMBL2802057 | 0.85 | FGFR1 (0.48) | FGFR1FGFR2MALT1S100A4 | |
| SCHEMBL2802254 | 0.85 | FGFR1 (0.49) | FGFR1FGFR2EGFRFGFR4FGFR3 | |
| SCHEMBL2806559 | 0.83 | FGFR1 (0.45) | FGFR1FGFR2MALT1S100A4EGFR | |
| SCHEMBL2489256 | 0.83 | FGFR1 (0.50) | FGFR1FGFR2MALT1S100A4EGFR | |
| SCHEMBL2803937 | 0.83 | FGFR1 (0.45) | FGFR1FGFR2MALT1EGFRFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |