Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489875 | 0.87 | FGFR1 (0.49) | FGFR1FGFR2KDM4EALDH1A1MAPT | |
| SCHEMBL2489649 | 0.68 | FGFR1 (0.72) | FGFR1FGFR2KDM4EALDH1A1POLB | |
| SCHEMBL2487628 | 0.68 | FGFR1 (0.72) | FGFR1FGFR2KDM4EALDH1A1POLB | |
| SCHEMBL2801922 | 0.67 | FGFR1 (1.00) | FGFR1FGFR2KDM4EALDH1A1ADORA2A | |
| SCHEMBL2803684 | 0.67 | FGFR1 (1.00) | FGFR1FGFR2KDM4EALDH1A1ADORA2A | |
| SCHEMBL2804089 | 0.67 | FGFR1 (1.00) | FGFR1FGFR2KDM4EALDH1A1ADORA2A | |
| SCHEMBL10069660 | 0.61 | MAPT (0.46) | KDM4EALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL2802921 | 0.61 | FGFR1 (0.72) | FGFR1FGFR2KDM4EALDH1A1MAPT | |
| SCHEMBL2802926 | 0.61 | FGFR1 (0.72) | FGFR1FGFR2KDM4EALDH1A1MAPT | |
| SCHEMBL2803623 | 0.59 | FGFR1 (0.61) | FGFR1FGFR2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |