Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 13/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 11/20 | 0.35 |
| ▸ | FLT3 | P36888 | 8/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 8/20 | 0.35 |
| ▸ | AXL | P30530 | 7/20 | 0.35 |
| ▸ | DNM2 | P50570 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489018 | 0.93 | FGFR1 (0.41) | FGFR1FGFR2CSF1RFGFR3MERTK | |
| SCHEMBL2802907 | 0.93 | FGFR1 (0.41) | FGFR1FGFR2CSF1RFGFR3MERTK | |
| SCHEMBL2489019 | 0.93 | FGFR1 (0.41) | FGFR1FGFR2CSF1RFGFR3MERTK | |
| SCHEMBL2513190 | 0.89 | FGFR1 (0.40) | FGFR1FGFR2FGFR3 | |
| SCHEMBL2513192 | 0.89 | FGFR1 (0.40) | FGFR1FGFR2FGFR3 | |
| SCHEMBL2807869 | 0.84 | FGFR1 (0.41) | FGFR1FGFR2CSF1RFGFR3FLT3 | |
| SCHEMBL2807870 | 0.84 | FGFR1 (0.41) | FGFR1FGFR2CSF1RFGFR3FLT3 | |
| SCHEMBL14644885 | 0.84 | FGFR1 (0.41) | FGFR1FGFR2CSF1RFGFR3FLT3 | |
| SCHEMBL2803900 | 0.79 | FGFR1 (0.54) | FGFR1FGFR2CSF1RFGFR3MERTK | |
| SCHEMBL2808949 | 0.78 | FGFR1 (0.49) | FGFR1FGFR2CSF1RFGFR3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379506-B1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE INC (US) | 2015-09-02 | — | — | EP | disclosed |
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |