Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2809268 | 0.89 | FGFR1 (0.47) | FGFR1FGFR2KDM4EHPGDCYP1A2 | |
| SCHEMBL2804835 | 0.85 | FGFR1 (0.49) | FGFR1FGFR2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2809551 | 0.85 | FGFR1 (0.49) | FGFR1FGFR2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2804218 | 0.85 | FGFR1 (0.49) | FGFR1FGFR2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2803624 | 0.85 | FGFR1 (0.42) | FGFR1FGFR2KDM4EHPGDCYP1A2 | |
| SCHEMBL2804806 | 0.84 | FGFR1 (0.46) | FGFR1FGFR2KDM4EHPGDCYP1A2 | |
| SCHEMBL2803882 | 0.84 | FGFR1 (0.42) | FGFR1FGFR2KDM4EHPGDCYP1A2 | |
| SCHEMBL2802550 | 0.84 | FGFR1 (0.42) | FGFR1FGFR2KDM4EHPGDCYP1A2 | |
| SCHEMBL2802852 | 0.83 | FGFR1 (0.41) | FGFR1FGFR2KDM4EHPGDCYP1A2 | |
| SCHEMBL2490169 | 0.83 | FGFR1 (0.50) | FGFR1FGFR2CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |