Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 16/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2802691 | 0.94 | FGFR1 (0.54) | FGFR1EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL2805479 | 0.90 | FGFR1 (0.50) | FGFR1EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL2804892 | 0.89 | FGFR1 (0.49) | FGFR1EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL2805974 | 0.89 | FGFR1 (0.49) | FGFR1EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL2802880 | 0.88 | FGFR1 (0.58) | FGFR1EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL2806260 | 0.87 | FGFR1 (0.47) | FGFR1EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL2807744 | 0.87 | FGFR1 (0.46) | FGFR1EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL2803074 | 0.87 | FGFR1 (0.51) | FGFR1EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL2806783 | 0.87 | FGFR1 (0.48) | FGFR1EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL2807118 | 0.87 | FGFR1 (0.51) | FGFR1EGFRFGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010078421-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |