Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3327785 | 0.90 | SCN9A (0.75) | SCN9A | |
| SCHEMBL12315006 | 0.88 | SCN9A (0.65) | SCN9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2304226 | 0.88 | SCN9A (0.65) | SCN9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2304153 | 0.87 | SCN9A (0.76) | SCN9A | |
| SCHEMBL385222 | 0.87 | SCN9A (0.75) | SCN9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2304156 | 0.87 | SCN9A (0.72) | SCN9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3329258 | 0.87 | SCN9A (0.72) | SCN9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL282057 | 0.86 | SCN9A (0.71) | SCN9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3334965 | 0.86 | SCN9A (0.71) | SCN9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL18774612 | 0.86 | SCN9A (0.71) | SCN9ACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350090-B1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2015-06-03 | — | — | EP | disclosed |
| WO-2010045251-A2 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS, INC. (CA) | 2010-04-22 | — | — | WO | disclosed |