SCHEMBL16366105

SCHEMBL16366105

CSC[C@H]1N[C@@H](c2c[nH]c3c(N)ncnc23)[C@@H](O)C1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MTAP Q13126 16/20 1.00
PNP P00491 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12723446 1.00 MTAP (1.00) MTAPPNP
SCHEMBL13137591 1.00 MTAP (1.00) MTAPPNP
SCHEMBL14262857 1.00 MTAP (1.00) MTAPPNP
SCHEMBL1222347 1.00 MTAP (1.00) MTAPPNP
SCHEMBL30924343 1.00 MTAP (1.00) MTAPPNP
SCHEMBL30583390 1.00 MTAP (1.00) MTAPPNP
Hydrochloric Acid SCHEMBL1222615 0.99 MTAP (1.00) MTAPPNP
SCHEMBL13464019 0.89 MTAP (0.81) MTAPPNP
SCHEMBL15593319 0.89 MTAP (0.98) MTAPPNP
SCHEMBL15593317 0.87 MTAP (0.98) MTAPPNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8916571-B2 Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) 2014-12-23 US disclosed