Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.75 |
| ▸ | MAP2K2 | P36507 | 8/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.75 |
| ▸ | BRAF | P15056 | 1/20 | 0.75 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.75 |
| ▸ | PIM1 | P11309 | 1/20 | 0.65 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17409930 | 0.93 | MAP2K1 (0.72) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL4861147 | 0.91 | MAP2K1 (0.77) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL18699256 | 0.89 | MAP2K1 (0.69) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL19534254 | 0.87 | MAP2K1 (0.80) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL4748567 | 0.86 | MAP2K1 (0.78) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL4859890 | 0.85 | MAP2K1 (0.85) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL20435083 | 0.85 | MAP2K1 (0.85) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| Mirdametinib SCHEMBL29358470 | 0.85 | MAP2K1 (1.00) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| Mirdametinib SCHEMBL895854 | 0.85 | MAP2K1 (1.00) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| Mirdametinib SCHEMBL29352748 | 0.85 | MAP2K1 (1.00) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014204856-A1 | FATTY ACID ANTICANCER DERIVATIVES AND THEIR USES | CATABASIS PHARMACEUTICALS, INC. (US) | 2014-12-24 | — | — | WO | disclosed |