Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.84 |
| ▸ | PLK4 | O00444 | 2/20 | 0.84 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.84 |
| ▸ | ABL1 | P00519 | 2/20 | 0.84 |
| ▸ | EGFR | P00533 | 2/20 | 0.84 |
| ▸ | LCK | P06239 | 2/20 | 0.84 |
| ▸ | FYN | P06241 | 2/20 | 0.84 |
| ▸ | CDK1 | P06493 | 2/20 | 0.84 |
| ▸ | RET | P07949 | 2/20 | 0.84 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.84 |
| ▸ | SRC | P12931 | 2/20 | 0.84 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.84 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.84 |
| ▸ | MARK3 | P27448 | 2/20 | 0.84 |
| ▸ | KDR | P35968 | 2/20 | 0.84 |
| ▸ | FLT3 | P36888 | 2/20 | 0.84 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.84 |
| ▸ | BTK | Q06187 | 2/20 | 0.84 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.84 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14502695 | 0.94 | AURKA (0.84) | AURKAPLK4CHEK2ABL1EGFR | |
| SCHEMBL16366040 | 0.92 | AURKA (0.83) | AURKAPLK4CHEK2ABL1EGFR | |
| SCHEMBL31517136 | 0.91 | AAK1 (1.00) | AURKAPLK4CHEK2ABL1EGFR | |
| SCHEMBL13987443 | 0.91 | AAK1 (1.00) | AURKAPLK4CHEK2ABL1EGFR | |
| SCHEMBL13599879 | 0.91 | AAK1 (1.00) | AURKAPLK4CHEK2ABL1EGFR | |
| SCHEMBL16366082 | 0.85 | AURKA (0.69) | AURKAPLK4CHEK2ABL1EGFR | |
| SCHEMBL16366569 | 0.84 | AURKA (0.67) | AURKAPLK4CHEK2ABL1EGFR | |
| SCHEMBL14396960 | 0.83 | AURKA (0.75) | AURKAPLK4CHEK2ABL1EGFR | |
| SCHEMBL14503108 | 0.83 | AURKA (0.69) | AURKAPLK4CHEK2ABL1EGFR | |
| SCHEMBL4808134 | 0.81 | AURKB (0.79) | AURKAPLK4CHEK2ABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014204856-A1 | FATTY ACID ANTICANCER DERIVATIVES AND THEIR USES | CATABASIS PHARMACEUTICALS, INC. (US) | 2014-12-24 | — | — | WO | disclosed |