Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 8/20 | 0.52 |
| ▸ | PDE1A | P54750 | 7/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 7/20 | 0.52 |
| ▸ | PDE2A | O00408 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462950 | 0.91 | PDE1B (0.50) | PDE1BPDE1APDE1CPDE2AMAPT | |
| SCHEMBL9608325 | 0.90 | PDE1A (0.41) | PDE1BPDE1APDE1CPDE2ABRD4 | |
| SCHEMBL2454720 | 0.90 | PDE1B (0.50) | PDE1BPDE1APDE1CPDE2AMAPT | |
| SCHEMBL9608334 | 0.87 | PDE1B (0.52) | PDE1BPDE1APDE1CPDE2AMAPT | |
| SCHEMBL2458078 | 0.85 | PDE1B (0.45) | PDE1BPDE1APDE1CPDE2AMAPT | |
| SCHEMBL2461370 | 0.85 | PDE1A (0.49) | PDE1BPDE1APDE1CPDE2AMAPT | |
| SCHEMBL2454858 | 0.84 | PDE1A (0.48) | PDE1BPDE1APDE1CPDE2ASLC16A1 | |
| SCHEMBL2455942 | 0.84 | PDE1B (0.48) | PDE1BPDE1APDE1CPDE2AMAPT | |
| SCHEMBL9609218 | 0.84 | PDE1B (0.48) | PDE1BPDE1APDE1CPDE2AMAPT | |
| SCHEMBL9608337 | 0.84 | PDE1B (0.48) | PDE1BPDE1APDE1CPDE2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927556-B2 | 1H-pyrrolo[3,4-D]pyrimidin-2(6H)-one compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2015-01-06 | — | — | US | disclosed |
| US-8927556-B2 | 1H-pyrrolo[3,4-D]pyrimidin-2(6H)-one compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2015-01-06 | — | — | US | disclosed |