Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5467893 | 0.80 | EGFR (0.70) | EGFRERBB2RETERBB4HDAC3 | |
| SCHEMBL5465521 | 0.72 | EGFR (0.71) | EGFRERBB2RETERBB4HDAC3 | |
| SCHEMBL5466827 | 0.72 | EGFR (0.59) | EGFRERBB2RETERBB4 | |
| SCHEMBL5469496 | 0.71 | EGFR (0.65) | EGFRERBB2RETERBB4HDAC3 | |
| SCHEMBL4740837 | 0.71 | EGFR (0.74) | EGFRERBB2RETERBB4HDAC3 | |
| SCHEMBL5464067 | 0.70 | EGFR (0.68) | EGFRERBB2RETERBB4HDAC3 | |
| SCHEMBL5465513 | 0.70 | EGFR (0.60) | EGFRERBB2RETERBB4HDAC3 | |
| SCHEMBL5462878 | 0.70 | EGFR (0.58) | EGFRERBB2RETERBB4HDAC3 | |
| SCHEMBL5469233 | 0.70 | EGFR (0.60) | EGFRERBB2RETERBB4 | |
| SCHEMBL5465619 | 0.70 | EGFR (0.63) | EGFRERBB2RETERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015000959-A1 | 4-AMINO-6-ARYL[2,3-D]PYRIMIDINES FOR THE INHIBITION OF EGFR TYROSINE KINASE | NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU) (NO) | 2015-01-08 | — | — | WO | disclosed |