Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 3/20 | 0.38 |
| ▸ | GUCY1A2 | P33402 | 3/20 | 0.38 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.38 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 13/20 | 0.36 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16376343 | 1.00 | GUCY1B2 (0.38) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1AADAT | |
| SCHEMBL14494146 | 0.85 | JAK1 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1JAK3 | |
| SCHEMBL14494151 | 0.85 | JAK1 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1JAK3 | |
| SCHEMBL10044624 | 0.81 | GUCY1B2 (0.40) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1AADAT | |
| SCHEMBL10044611 | 0.81 | GUCY1B2 (0.40) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1AADAT | |
| SCHEMBL2630353 | 0.79 | JAK3 (0.55) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1JAK3 | |
| SCHEMBL2630352 | 0.79 | JAK3 (0.55) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1JAK3 | |
| SCHEMBL13305968 | 0.79 | GUCY1B2 (0.40) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1AADAT | |
| SCHEMBL10044597 | 0.78 | F2 (0.41) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1AADAT | |
| SCHEMBL10044617 | 0.78 | F2 (0.41) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1AADAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921376-B2 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-12-30 | — | — | US | disclosed |