Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.56 |
| ▸ | MTOR | P42345 | 16/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.47 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.47 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.47 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1309387 | 0.86 | MTOR (0.56) | PIK3CAMTORPIK3R1PIK3CBRICTOR | |
| SCHEMBL18117903 | 0.82 | PIK3CA (0.51) | PIK3CAMTORPIK3R1HTTTSHR | |
| SCHEMBL1310035 | 0.82 | PIK3CA (0.59) | PIK3CAMTORPIK3R1PIK3CBRICTOR | |
| SCHEMBL1308487 | 0.79 | PIK3CA (0.68) | PIK3CAMTORPIK3R1PIK3CBRICTOR | |
| SCHEMBL1309147 | 0.79 | PIK3CA (0.59) | PIK3CAMTORPIK3R1PIK3CBRICTOR | |
| SCHEMBL1310917 | 0.79 | PIK3CA (0.59) | PIK3CAMTORPIK3R1PIK3CBRICTOR | |
| SCHEMBL1309557 | 0.79 | PIK3CA (0.59) | PIK3CAMTORPIK3R1PIK3CBRICTOR | |
| SCHEMBL1311771 | 0.78 | PIK3CA (0.56) | PIK3CAMTORPIK3R1PIK3CBRICTOR | |
| SCHEMBL18117908 | 0.77 | PIK3CA (0.54) | PIK3CAMTORPIK3R1PIK3CBRICTOR | |
| SCHEMBL1312053 | 0.77 | PIK3CA (0.57) | PIK3CAMTORPIK3R1PIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921361-B2 | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes | UNIVERSITY OF BASEL (CH) | 2014-12-30 | — | — | US | disclosed |