Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 18/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | FAP | Q12884 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777362 | 0.79 | DDR1 (0.51) | — | |
| SCHEMBL16380700 | 0.78 | DDR1 (0.50) | — | |
| SCHEMBL3311056 | 0.76 | NR1H2 (0.52) | — | |
| SCHEMBL16380735 | 0.76 | NR1H2 (0.49) | EGFRBRAF | |
| SCHEMBL2707620 | 0.76 | NR1H2 (0.66) | EGFRBRAF | |
| SCHEMBL16380771 | 0.75 | NR1H2 (0.51) | EGFRBRAF | |
| SCHEMBL29921818 | 0.74 | PDE3B (0.50) | BRAF | |
| SCHEMBL2709582 | 0.74 | PDE3B (0.50) | BRAF | |
| SCHEMBL2707963 | 0.74 | DDR1 (0.53) | — | |
| SCHEMBL2707798 | 0.73 | DDR1 (0.56) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670231-B2 | Fused tricyclic amide compounds as multiple kinase inhibitors | BEIGENE, LTD. (KY) | 2017-06-06 | — | — | US | disclosed |
| WO-2014206344-A1 | FUSED TRICYCLIC AMIDE COMPOUNDS AS MULTIPLE KINASE INHIBITORS | BEIGENE, LTD. (GB) | 2014-12-31 | — | — | WO | disclosed |