Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 11/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16381669 | 0.93 | IL2 (0.46) | IL2TRPM8RAF1KCNH2TNF | |
| SCHEMBL16381734 | 0.88 | IL2 (0.49) | IL2TRPM8RAF1KCNH2ACACB | |
| SCHEMBL16339787 | 0.86 | IL2 (0.53) | IL2TRPM8RAF1KCNH2TNF | |
| SCHEMBL17762912 | 0.85 | IL2 (0.56) | IL2TRPM8RAF1KCNH2TNF | |
| SCHEMBL16381688 | 0.84 | IL2 (0.50) | IL2TRPM8RAF1KCNH2TNF | |
| Hydrochloric Acid SCHEMBL16334767 | 0.83 | IL2 (0.49) | IL2TRPM8RAF1KCNH2TNF | |
| SCHEMBL16335019 | 0.83 | IL2 (0.49) | IL2TRPM8RAF1KCNH2TNF | |
| SCHEMBL16339632 | 0.83 | IL2 (0.51) | IL2TRPM8RAF1KCNH2TNF | |
| SCHEMBL16339606 | 0.83 | IL2 (0.49) | IL2TRPM8RAF1KCNH2TNF | |
| SCHEMBL16339225 | 0.83 | IL2 (0.53) | IL2TRPM8RAF1KCNH2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790231-B2 | Chromane and chromene derivatives and their use as CRAC modulators | LUPIN LIMITED (IN) | 2017-10-17 | — | — | US | disclosed |
| WO-2014207648-A1 | CHROMANE AND CHROMENE DERIVATIVES AND THEIR USE AS CRAC MODULATORS | LUPIN LIMITED (IN) | 2014-12-31 | — | — | WO | disclosed |