Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 18/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL960914 | 0.90 | NPY1R (0.64) | NPY1RKCNH2 | |
| SCHEMBL962961 | 0.88 | NPY1R (0.50) | NPY1RKCNH2 | |
| SCHEMBL166049 | 0.83 | NPY1R (0.51) | NPY1RKCNH2SCN9A | |
| SCHEMBL961779 | 0.83 | NPY1R (0.65) | NPY1RKCNH2 | |
| SCHEMBL963884 | 0.83 | NPY1R (0.51) | NPY1RKCNH2SCN9A | |
| SCHEMBL962901 | 0.82 | NPY1R (0.57) | NPY1RKCNH2 | |
| SCHEMBL12914806 | 0.81 | NPY1R (0.44) | NPY1RKCNH2SCN9A | |
| SCHEMBL503981 | 0.80 | KCNQ3 (0.36) | NPY1RKCNH2SCN9A | |
| SCHEMBL7020361 | 0.79 | NPY1R (0.37) | NPY1RKCNH2SCN9A | |
| SCHEMBL962152 | 0.77 | NPY1R (0.66) | NPY1RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424860-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | MSD K.K. (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | MSD K.K. (JP) | 2012-02-02 | — | — | US | disclosed |
| US-20110015181-A1 | ALKYLAMINOPYRIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-01-20 | — | — | US | disclosed |
| WO-2010126163-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | AR, NR5A1, ARL1 | NPY1R 354/4885KCNH2 3202/4885SCN9A 3772/4885 |
| US-20110015181-A1 | ALKYLAMINOPYRIDINE DERIVATIVE | NPY4R, NPY1R, NPY2R | NPY1R 2/4885KCNH2 1295/4885SCN9A 2005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.