Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 5/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026512 | 1.00 | MAPT (0.55) | MAPTUSP2MAPK1HRH3KDM4E | |
| SCHEMBL216758 | 1.00 | MAPT (0.55) | MAPTUSP2MAPK1HRH3KDM4E | |
| SCHEMBL16380827 | 1.00 | MAPT (0.55) | MAPTUSP2MAPK1HRH3KDM4E | |
| SCHEMBL218239 | 0.90 | MAPT (0.52) | MAPTUSP2MAPK1HRH3KDM4E | |
| SCHEMBL218440 | 0.89 | MAPT (0.57) | MAPTUSP2MAPK1HRH3KDM4E | |
| SCHEMBL219511 | 0.89 | MAPT (0.57) | MAPTUSP2MAPK1HRH3KDM4E | |
| SCHEMBL220192 | 0.89 | MAPT (0.60) | MAPTUSP2MAPK1HRH3KDM4E | |
| SCHEMBL217697 | 0.89 | MAPT (0.60) | MAPTUSP2MAPK1HRH3KDM4E | |
| SCHEMBL219223 | 0.89 | MAPT (0.57) | MAPTUSP2MAPK1HRH3KDM4E | |
| SCHEMBL962992 | 0.87 | MAPT (0.53) | MAPTUSP2MAPK1HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014207311-A1 | THERAPEUTICALLY ACTIVE ESTRATRIENTHIAZOLE DERIVATIVES AS INHIBITORS OF 17.BETA.-HYDROXY-STEROID DEHYDROGENASE, TYPE 1 | FORENDO PHARMA LTD (FI) | 2014-12-31 | — | — | WO | disclosed |