Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.81 |
| ▸ | EGFR | P00533 | 5/20 | 0.81 |
| ▸ | INSR | P06213 | 6/20 | 0.68 |
| ▸ | IGF1R | P08069 | 6/20 | 0.68 |
| ▸ | AURKA | O14965 | 2/20 | 0.68 |
| ▸ | ROS1 | P08922 | 2/20 | 0.68 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.68 |
| ▸ | PLK1 | P53350 | 2/20 | 0.64 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.62 |
| ▸ | CDC7 | O00311 | 1/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.61 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19766686 | 0.93 | ALK (0.79) | ALKEGFRINSRIGF1RAURKA | |
| SCHEMBL16371126 | 0.92 | ALK (0.78) | ALKEGFRINSRIGF1RAURKA | |
| SCHEMBL16372087 | 0.92 | ALK (0.85) | ALKEGFRINSRIGF1RAURKA | |
| SCHEMBL16371168 | 0.92 | ALK (0.85) | ALKEGFRINSRIGF1RAURKA | |
| SCHEMBL16385713 | 0.91 | ALK (0.82) | ALKEGFRINSRIGF1RAURKA | |
| SCHEMBL16371316 | 0.90 | ALK (0.87) | ALKEGFRINSRIGF1RAURKA | |
| SCHEMBL16371266 | 0.90 | ALK (0.87) | ALKEGFRINSRIGF1RAURKA | |
| SCHEMBL16371599 | 0.90 | ALK (0.81) | ALKEGFRINSRIGF1RAURKA | |
| SCHEMBL16371604 | 0.90 | ALK (0.86) | ALKEGFRINSRIGF1RAURKA | |
| SCHEMBL16371803 | 0.90 | ALK (1.00) | ALKEGFRINSRIGF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015003658-A1 | PROTEIN TYROSINE KINASE MODULATORS AND METHODS OF USE | BETTA PHARMACEUTICALS CO., LTD (CN) | 2015-01-15 | — | — | WO | disclosed |