Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 19/20 | 0.80 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.80 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.68 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868637 | 0.89 | EIF2AK3 (1.00) | EIF2AK3RIPK1EIF2AK2EIF2AK1 | |
| SCHEMBL869512 | 0.86 | EIF2AK3 (0.84) | EIF2AK3RIPK1EIF2AK2EIF2AK1 | |
| SCHEMBL869055 | 0.86 | EIF2AK3 (0.83) | EIF2AK3RIPK1EIF2AK2EIF2AK1 | |
| SCHEMBL868551 | 0.85 | EIF2AK3 (1.00) | EIF2AK3RIPK1EIF2AK2EIF2AK1 | |
| SCHEMBL869470 | 0.85 | EIF2AK3 (1.00) | EIF2AK3RIPK1EIF2AK2EIF2AK1 | |
| SCHEMBL868476 | 0.85 | EIF2AK3 (0.87) | EIF2AK3RIPK1EIF2AK2EIF2AK1 | |
| SCHEMBL868232 | 0.84 | EIF2AK3 (1.00) | EIF2AK3RIPK1EIF2AK2EIF2AK1 | |
| SCHEMBL867997 | 0.84 | EIF2AK3 (0.85) | EIF2AK3RIPK1EIF2AK2EIF2AK1 | |
| SCHEMBL869173 | 0.84 | EIF2AK3 (0.88) | EIF2AK3RIPK1EIF2AK2EIF2AK1 | |
| SCHEMBL27975780 | 0.83 | EIF2AK3 (0.87) | EIF2AK3RIPK1EIF2AK2EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |