Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DHCR7 | Q9UBM7 | 3/20 | 0.33 |
| ▸ | EBP | Q15125 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.30 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.30 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22737161 | 0.82 | KDM4E (0.40) | KDM4EPOLBDHCR7EBPMEN1 | |
| SCHEMBL25215290 | 0.81 | — | — | |
| SCHEMBL156650 | 0.81 | KDM4E (0.41) | KDM4EPOLBDHCR7EBPMEN1 | |
| SCHEMBL26761797 | 0.79 | — | — | |
| SCHEMBL24995242 | 0.78 | — | — | |
| SCHEMBL31327023 | 0.77 | PHGDH (0.30) | PHGDHMGLL | |
| SCHEMBL26118274 | 0.76 | KDM4E (0.47) | KDM4EPOLBDHCR7EBPMEN1 | |
| SCHEMBL82615 | 0.76 | KDM4E (0.47) | KDM4EPOLBDHCR7EBPMEN1 | |
| SCHEMBL10203441 | 0.76 | KDM4E (0.42) | KDM4EPOLBDHCR7EBPMEN1 | |
| SCHEMBL10203439 | 0.76 | KDM4E (0.42) | KDM4EPOLBDHCR7EBPMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781640-B1 | 2,4-DI(AMINOPHENYL)PYRIMIDINE DERIVATIVES AS PLK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2015-01-07 | — | — | EP | disclosed |