Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 11/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15728680 | 0.93 | FGFR3 (0.55) | FGFR3FGFR4FGFR1FGFR2KCNH2 | |
| SCHEMBL15728596 | 0.93 | FGFR3 (0.55) | FGFR3FGFR4FGFR1FGFR2KCNH2 | |
| SCHEMBL18132757 | 0.88 | FGFR3 (0.49) | FGFR3FGFR4FGFR1FGFR2KCNH2 | |
| SCHEMBL18132745 | 0.88 | FGFR3 (0.49) | FGFR3FGFR4FGFR1FGFR2KCNH2 | |
| SCHEMBL21280290 | 0.87 | FGFR3 (0.61) | FGFR3FGFR4FGFR1FGFR2KCNH2 | |
| SCHEMBL15709948 | 0.85 | FGFR3 (0.61) | FGFR3FGFR4FGFR1FGFR2KCNH2 | |
| SCHEMBL15709822 | 0.83 | FGFR3 (0.56) | FGFR3FGFR4FGFR1FGFR2KCNH2 | |
| SCHEMBL15728632 | 0.80 | FGFR3 (0.55) | FGFR3FGFR4FGFR1FGFR2KCNH2 | |
| SCHEMBL18132769 | 0.80 | FGFR3 (0.55) | FGFR3FGFR4FGFR1FGFR2KCNH2 | |
| SCHEMBL15728617 | 0.79 | FGFR3 (0.54) | FGFR3FGFR4FGFR1FGFR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2821402-A1 | NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND | Astellas Pharma Inc. (JP) | 2015-01-07 | — | — | EP | disclosed |