Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tripelennamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.72 |
| ▸ | DRD1 | P21728 | 4/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.72 |
| ▸ | HTR2A | P28223 | 3/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.72 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tripelennamine SCHEMBL17970 | 0.85 | CHRM2 (1.00) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL29600775 | 0.85 | CHRM2 (1.00) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL98916 | 0.84 | KDM4E (1.00) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL1652325 | 0.84 | CHRM2 (0.97) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL29363256 | 0.84 | KDM4E (1.00) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL15270438 | 0.80 | CHRM2 (0.89) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Chloropyramine SCHEMBL13723581 | 0.78 | CYP2D6 (0.95) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Tripelennamine SCHEMBL5432608 | 0.77 | CHRM2 (0.82) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| Methylpromazine SCHEMBL21142963 | 0.76 | CHRM2 (0.60) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL16491454 | 0.76 | CHRM2 (0.81) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060193789-A1 | Surfacant, film forming agent, water, gas propellant; plant and animal extracts and oils; may include malathion | FOAMIX LTD. (IL) | 2006-08-31 | — | — | US | claimed |
| US-20190076339-A1 | FOAMABLE COMPOSITION COMBINING A POLAR SOLVENT AND A HYDROPHOBIC CARRIER | VYNE PHARMACEUTICALS LTD. (F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2019-03-14 | — | — | US | disclosed |
| US-10117812-B2 | Foamable composition combining a polar solvent and a hydrophobic carrier | FOAMIX PHARMACEUTICALS LTD. (IL) | 2018-11-06 | — | — | US | disclosed |
| US-20170172857-A1 | FOAMABLE COMPOSITION COMBINING A POLAR SOLVENT AND A HYDROPHOBIC CARRIER | FOAMIX PHARMACEUTICALS LTD. | 2017-06-22 | — | — | US | disclosed |
| US-9682021-B2 | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses | FOAMIX PHARMACEUTICALS LTD. (IL) | 2017-06-20 | — | — | US | disclosed |
| US-9622947-B2 | Foamable composition combining a polar solvent and a hydrophobic carrier | FOAMIX PHARMACEUTICALS LTD. (IL) | 2017-04-18 | — | — | US | disclosed |
| US-20140248219-A1 | SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES | FOAMIX LTD. (IL) | 2014-09-04 | — | — | US | disclosed |
| US-8795635-B2 | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses | FOAMIX LTD. (IL) | 2014-08-05 | — | — | US | disclosed |
| US-20130189196-A1 | Foamable Composition | FOAMIX LTD. (IL) | 2013-07-25 | — | — | US | disclosed |
| US-20110097279-A1 | STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES | FOAMIX LTD. (IL) | 2011-04-28 | — | — | US | disclosed |
| US-20100221195-A1 | SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES | FOAMIX LTD. (IL) | 2010-09-02 | — | — | US | disclosed |
| US-20090180970-A1 | FOAMABLE COMPOSITION COMBINING A POLAR SOLVENT AND A HYDROPHOBIC CARRIER | FOAMIX LTD. (IL) | 2009-07-16 | — | — | US | disclosed |
| EP-2073794-A2 | STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES | Foamix Ltd. (IL) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009007785-A2 | STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES | FOAMIX LTD. (US) | 2009-01-15 | — | — | WO | disclosed |
| US-20080260655-A1 | stable, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum, foam agent, propellant, | FOAMIX PHARMACEUTICALS LTD. (IL) | 2008-10-23 | — | — | US | disclosed |
| US-20080206155-A1 | STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES | FOAMIX LTD. | 2008-08-28 | — | — | US | disclosed |
| WO-2007085902-A2 | FOAMABLE COMPOSITION COMBINING A POLAR SOLVENT AND A HYDROPHOBIC CARRIER | FOAMIX LTD. (US) | 2007-08-02 | — | — | WO | disclosed |
| US-20070020213-A1 | Surfactant, water, plant and animal extracts and oils, compressed gas propellant; topical application of cosmetic or pharmaceuticals | FOAMIX LTD. (IL) | 2007-01-25 | — | — | US | disclosed |
| US-20060193789-A1 | Surfacant, film forming agent, water, gas propellant; plant and animal extracts and oils; may include malathion | FOAMIX LTD. (IL) | 2006-08-31 | — | — | US | disclosed |