Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 17/20 | 0.98 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.82 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.82 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.82 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.82 |
| ▸ | CDK1 | P06493 | 3/20 | 0.53 |
| ▸ | CDK4 | P11802 | 3/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.53 |
| ▸ | CCND1 | P24385 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.53 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
| ▸ | PIK3R4 | Q99570 | 1/20 | 0.49 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15754843 | 0.99 | PIK3C3 (1.00) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL16390779 | 0.98 | PIK3C3 (0.94) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL16390922 | 0.90 | PIK3C3 (1.00) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL16390818 | 0.90 | PIK3C3 (1.00) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9957886 | 0.90 | PIK3C3 (1.00) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL16390650 | 0.89 | PIK3C3 (0.79) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL16390652 | 0.89 | PIK3C3 (0.78) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL16390653 | 0.89 | PIK3C3 (0.78) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL10089562 | 0.86 | PIK3C3 (0.83) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL16390921 | 0.82 | PIK3C3 (1.00) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655340-B1 | BI-HETEROARYL COMPOUNDS AS VPS34 INHIBITORS | NOVARTIS AG (CH) | 2015-01-21 | — | — | EP | disclosed |