Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.69 |
| ▸ | DPP4 | P27487 | 1/20 | 0.58 |
| ▸ | RRM1 | P23921 | 5/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 10/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.56 |
| ▸ | ALPI | P09923 | 1/20 | 0.56 |
| ▸ | ALPG | P10696 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | KLF5 | Q13887 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12767346 | 1.00 | SPHK1 (0.69) | SPHK1DPP4RRM1PAX8MEN1 | |
| SCHEMBL1639361 | 1.00 | SPHK1 (0.69) | SPHK1DPP4RRM1PAX8MEN1 | |
| SCHEMBL1639416 | 0.84 | SPHK1 (0.73) | SPHK1DPP4RRM1PAX8MEN1 | |
| SCHEMBL12767408 | 0.84 | SPHK1 (0.73) | SPHK1DPP4RRM1PAX8MEN1 | |
| SCHEMBL1639418 | 0.84 | SPHK1 (0.73) | SPHK1DPP4RRM1PAX8MEN1 | |
| SCHEMBL19182739 | 0.82 | SPHK1 (1.00) | SPHK1DPP4RRM1PAX8MEN1 | |
| SCHEMBL30899246 | 0.82 | SPHK1 (1.00) | SPHK1DPP4RRM1PAX8MEN1 | |
| SCHEMBL19182914 | 0.82 | SPHK1 (1.00) | SPHK1DPP4RRM1PAX8MEN1 | |
| SCHEMBL14501922 | 0.82 | SPHK1 (1.00) | SPHK1DPP4RRM1PAX8MEN1 | |
| SCHEMBL8298508 | 0.82 | SPHK1 (0.85) | SPHK1DPP4RRM1PAX8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | ACUMEN PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | APP, APBA1, BACE1 | SPHK1 2935/4885DPP4 645/4885RRM1 3099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.