Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.46 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 14/20 | 0.36 |
| ▸ | JAK1 | P23458 | 13/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16394841 | 1.00 | SYK (0.46) | SYKEIF2AK4CAMK1DULK1JAK2 | |
| SCHEMBL19970672 | 0.93 | SYK (0.46) | SYKEIF2AK4CAMK1DULK1JAK2 | |
| SCHEMBL15210788 | 0.93 | SYK (0.46) | SYKEIF2AK4CAMK1DULK1JAK2 | |
| SCHEMBL19970666 | 0.90 | SYK (0.48) | SYKEIF2AK4CAMK1DULK1JAK2 | |
| SCHEMBL19970667 | 0.90 | SYK (0.48) | SYKEIF2AK4CAMK1DULK1JAK2 | |
| SCHEMBL15210775 | 0.89 | SYK (0.46) | SYKEIF2AK4CAMK1DJAK2JAK1 | |
| SCHEMBL15221229 | 0.88 | SYK (0.45) | SYKEIF2AK4CAMK1DJAK2JAK1 | |
| SCHEMBL19982953 | 0.88 | SYK (0.44) | SYKEIF2AK4CAMK1DJAK2JAK1 | |
| SCHEMBL15210630 | 0.88 | SYK (0.44) | SYKEIF2AK4CAMK1DJAK2JAK1 | |
| SCHEMBL16394610 | 0.88 | SYK (0.46) | SYKEIF2AK4CAMK1DJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150025058-A1 | 8 - SUBSTITUTED 2 -AMINO - [1,2,4] TRIAZOLO [1, 5 -A] PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2015-01-22 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025058-A1 | 8 - SUBSTITUTED 2 -AMINO - [1,2,4] TRIAZOLO [1, 5 -A] PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | SYK, EIF2AK4, BTK | SYK 1/4885EIF2AK4 2/4885CAMK1D 957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.