Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL16395696 | 1.00 | SLC7A5 (0.57) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| Threonine SCHEMBL5222431 | 1.00 | SLC7A5 (0.57) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| Threonine SCHEMBL18096480 | 0.94 | SLC7A5 (0.57) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| Threonine SCHEMBL18096482 | 0.94 | SLC7A5 (0.57) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| Threonine SCHEMBL6038228 | 0.94 | SLC7A5 (0.63) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| Threonine SCHEMBL117301 | 0.94 | — | — | |
| Threonine SCHEMBL18050157 | 0.94 | SLC7A5 (0.63) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| Threonine SCHEMBL16111860 | 0.94 | SLC7A5 (0.63) | SLC7A5TP53SLC1A3SLC1A2SLC1A1 | |
| Threonine SCHEMBL14946556 | 0.94 | — | — | |
| Threonine SCHEMBL92730 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022171-B1 | NEW SALTS, CRYSTALS, COMPLEXES, AND DERIVATIVES OF THREONINE DIACETIC ACID, A PROCESS TO PREPARE THREONINE DIACETIC ACID, AND THE USE THEREOF | AKZO NOBEL CHEMICALS INT BV (NL) | 2017-07-05 | — | — | EP | disclosed |
| EP-3022171-B1 | NEW SALTS, CRYSTALS, COMPLEXES, AND DERIVATIVES OF THREONINE DIACETIC ACID, A PROCESS TO PREPARE THREONINE DIACETIC ACID, AND THE USE THEREOF | AKZO NOBEL CHEMICALS INT BV (NL) | 2017-07-05 | — | — | EP | disclosed |
| US-9416095-B2 | Salts, crystals, complexes, and derivatives of threonine diacetic acid, a process to prepare threonine diacetic acid, and the use thereof | AKZO NOBEL CHEMICALS INTERNATIONAL B.V. (NL) | 2016-08-16 | — | — | US | disclosed |
| US-9416095-B2 | Salts, crystals, complexes, and derivatives of threonine diacetic acid, a process to prepare threonine diacetic acid, and the use thereof | AKZO NOBEL CHEMICALS INTERNATIONAL B.V. (NL) | 2016-08-16 | — | — | US | disclosed |
| US-20160159730-A1 | New Salts, Crystals, Complexes, and Derivatives of Threonine Diacetic Acid, a Process to Prepare threonine Diacetic Acid, and the Use Thereof | AKZO NOBEL CHEMICALS INTERNATIONAL B.V. | 2016-06-09 | — | — | US | disclosed |
| US-20160159730-A1 | New Salts, Crystals, Complexes, and Derivatives of Threonine Diacetic Acid, a Process to Prepare threonine Diacetic Acid, and the Use Thereof | AKZO NOBEL CHEMICALS INTERNATIONAL B.V. | 2016-06-09 | — | — | US | disclosed |
| EP-3022171-A1 | NEW SALTS, CRYSTALS, COMPLEXES, AND DERIVATIVES OF THREONINE DIACETIC ACID, A PROCESS TO PREPARE THREONINE DIACETIC ACID, AND THE USE THEREOF | Akzo Nobel Chemicals International B.V. (NL) | 2016-05-25 | — | — | EP | disclosed |
| EP-3022171-A1 | NEW SALTS, CRYSTALS, COMPLEXES, AND DERIVATIVES OF THREONINE DIACETIC ACID, A PROCESS TO PREPARE THREONINE DIACETIC ACID, AND THE USE THEREOF | Akzo Nobel Chemicals International B.V. (NL) | 2016-05-25 | — | — | EP | disclosed |
| CN-105377809-A | Novel salts, crystals, complexes and derivatives of threonine diacetic acid, process for preparing threonine diacetic acid and use thereof | AKZO NOBEL CHEMICALS INT BV | 2016-03-02 | — | — | CN | disclosed |
| WO-2015007630-A1 | NEW SALTS, CRYSTALS, COMPLEXES, AND DERIVATIVES OF THREONINE DIACETIC ACID, A PROCESS TO PREPARE THREONINE DIACETIC ACID, AND THE USE THEREOF | AKZO NOBEL CHEMICALS INTERNATIONAL B.V. (NL) | 2015-01-22 | — | — | WO | disclosed |
| WO-2015007630-A1 | NEW SALTS, CRYSTALS, COMPLEXES, AND DERIVATIVES OF THREONINE DIACETIC ACID, A PROCESS TO PREPARE THREONINE DIACETIC ACID, AND THE USE THEREOF | AKZO NOBEL CHEMICALS INTERNATIONAL B.V. (NL) | 2015-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159730-A1 | New Salts, Crystals, Complexes, and Derivatives of Threonine Diacetic Acid, a Process to Prepare threonine Diacetic Acid, and the Use Thereof | LRRK2, SKP2, PLK1 | SLC7A5 474/4885TP53 275/4885SLC1A3 1741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.