⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10593171 | 0.77 | MEN1 (0.45) | — | |
| SCHEMBL430949 | 0.76 | — | — | |
| SCHEMBL939722 | 0.74 | MEN1 (0.32) | — | |
| SCHEMBL1289421 | 0.74 | MEN1 (0.32) | — | |
| SCHEMBL419805 | 0.74 | MEN1 (0.32) | — | |
| SCHEMBL899910 | 0.69 | — | — | |
| SCHEMBL568342 | 0.69 | — | — | |
| SCHEMBL292853 | 0.69 | — | — | |
| SCHEMBL431029 | 0.69 | — | — | |
| SCHEMBL7534213 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022182-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009977-A1 | AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |