Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.74 |
| ▸ | MGAM | O43451 | 4/20 | 0.74 |
| ▸ | SI | P14410 | 3/20 | 0.74 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.74 |
| ▸ | AR | P10275 | 2/20 | 0.73 |
| ▸ | PGR | P06401 | 1/20 | 0.71 |
| ▸ | ECE2 | P0DPD6 | 2/20 | 0.70 |
| ▸ | ECE1 | P42892 | 2/20 | 0.70 |
| ▸ | MUS81 | Q96NY9 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.64 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.60 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12767281 | 1.00 | GAA (0.74) | GAAMGAMSIMGAM2AR | |
| SCHEMBL1639414 | 1.00 | GAA (0.74) | GAAMGAMSIMGAM2AR | |
| SCHEMBL12767404 | 0.89 | MAPT (0.64) | GAAMGAMSIMGAM2AR | |
| SCHEMBL1638671 | 0.89 | MAPT (0.64) | GAAMGAMSIMGAM2AR | |
| SCHEMBL1638669 | 0.89 | MAPT (0.64) | GAAMGAMSIMGAM2AR | |
| SCHEMBL1639490 | 0.88 | MGAM (0.67) | GAAMGAMSIMGAM2AR | |
| SCHEMBL1639491 | 0.88 | MGAM (0.67) | GAAMGAMSIMGAM2AR | |
| SCHEMBL12767328 | 0.88 | MGAM (0.67) | GAAMGAMSIMGAM2AR | |
| SCHEMBL12766807 | 0.88 | MGAM (0.63) | GAAMGAMSIMGAM2AR | |
| SCHEMBL1638171 | 0.88 | MGAM (0.63) | GAAMGAMSIMGAM2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | ACUMEN PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | US | disclosed |
| EP-2194975-A2 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-ß DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUNDS | Acumen Pharmaceuticals, Inc. (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009009768-A2 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-β DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS | ACUMEN PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098309-A1 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS | APP, APBA1, BACE1 | GAA 166/4885MGAM 1174/4885SI 1946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.