SCHEMBL16400271

SCHEMBL16400271

Cn1nc2c(ccc3cc(/C=N/SNC(=O)Nc4c(Cl)cccc4Cl)ccc32)c1-c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.34
MAPT P10636 1/20 0.34
CHRNA7 P36544 2/20 0.33
SCN10A Q9Y5Y9 2/20 0.33
IGF1R P08069 1/20 0.33
TP53 P04637 2/20 0.32
PTGS2 P35354 1/20 0.32
CACNA1H O95180 1/20 0.32
GCGR P47871 1/20 0.31
SCN2A Q99250 1/20 0.31
ITGB1 P05556 1/20 0.31
ITGA4 P13612 1/20 0.31
ITGB7 P26010 1/20 0.31
P2RY1 P47900 1/20 0.31
KDM5A P29375 1/20 0.31
KDM2B Q8NHM5 1/20 0.31
KDM4C Q9H3R0 1/20 0.31
KDM5B Q9UGL1 1/20 0.31
MRE11 P49959 1/20 0.31
MEN1 O00255 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16400798 0.96 CHRNA7 (0.39) HTR2AMAPTCHRNA7SCN10APTGS2
SCHEMBL16401073 0.92 HTR2A (0.34) HTR2AMAPTSCN10A
SCHEMBL16400619 0.91 TTK (0.34) HTR2AMAPTSCN10ATP53CACNA1H
SCHEMBL16401578 0.91 HTR2A (0.38) HTR2AMAPTSCN10ATP53CACNA1H
SCHEMBL16401400 0.88 PTPRC (0.33) HTR2AMAPTSCN10ATP53SCN2A
SCHEMBL16400162 0.88 GCGR (0.33) HTR2AMAPTGCGRP2RY1
SCHEMBL16400927 0.85 TRPV1 (0.38) HTR2AMAPTSCN10AP2RY1KDM5A
SCHEMBL16401042 0.84 MAPT (0.34) HTR2AMAPTTP53P2RY1KDM5A
SCHEMBL19315857 0.83 MEN1 (0.36) MAPTSCN10AGCGRMEN1NPC1
SCHEMBL16400273 0.83 NPC1 (0.36) MAPTGCGRMEN1NPC1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3022185-B1 PESTICIDE COMPOUNDS BASF SE (DE) 2017-09-06 EP claimed
US-9497970-B2 Pesticide compounds BASF SE (DE) 2016-11-22 US claimed
US-20160157491-A1 Pesticide Compounds BASF SE (DE) 2016-06-09 US claimed
EP-3022185-A1 PESTICIDE COMPOUNDS BASF SE (DE) 2016-05-25 EP claimed
WO-2015007682-A1 PESTICIDE COMPOUNDS BASF SE (DE) 2015-01-22 WO claimed
EP-3022185-B1 PESTICIDE COMPOUNDS BASF SE (DE) 2017-09-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160157491-A1 Pesticide Compounds C1R, C1S, CBR3 HTR2A 2883/4885MAPT 782/4885CHRNA7 261/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.