Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.73 |
| ▸ | PDE6C | P51160 | 2/20 | 0.61 |
| ▸ | PDE6D | O43924 | 1/20 | 0.61 |
| ▸ | PDE6A | P16499 | 1/20 | 0.61 |
| ▸ | PDE6G | P18545 | 1/20 | 0.61 |
| ▸ | PDE6B | P35913 | 1/20 | 0.61 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410983 | 0.85 | PDE5A (1.00) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL16210977 | 0.81 | PDE5A (1.00) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL16401770 | 0.78 | PDE5A (0.89) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL23295122 | 0.78 | PDE5A (0.90) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL16211000 | 0.77 | PDE5A (1.00) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL16211010 | 0.77 | PDE5A (1.00) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL17792390 | 0.76 | PDE5A (1.00) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL15131967 | 0.76 | PDE5A (1.00) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL16403389 | 0.75 | PDE5A (1.00) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL16403420 | 0.74 | PDE5A (0.82) | PDE5APDE6CPDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022205-A2 | NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009930-A2 | NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-01-22 | — | — | WO | disclosed |