Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 8/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.56 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 7/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758899 | 0.92 | MAPK10 (0.56) | MAPK10MAPK8TBK1MAPK9JAK2 | |
| SCHEMBL3764858 | 0.90 | MAPK10 (0.54) | MAPK10MAPK8TBK1MAPK9JAK2 | |
| SCHEMBL3756434 | 0.90 | MAPK10 (0.62) | MAPK10MAPK8TBK1MAPK9JAK2 | |
| SCHEMBL3754746 | 0.87 | MAPK10 (0.59) | MAPK10MAPK8TBK1MAPK9JAK2 | |
| SCHEMBL3756008 | 0.86 | MAPK10 (0.55) | MAPK10MAPK8TBK1MAPK9JAK2 | |
| SCHEMBL3763094 | 0.86 | MAPK10 (0.61) | MAPK10MAPK8TBK1MAPK9JAK2 | |
| SCHEMBL3759004 | 0.85 | MAPK10 (0.74) | MAPK10MAPK8TBK1MAPK9JAK2 | |
| SCHEMBL3753592 | 0.85 | MAPK10 (0.62) | MAPK10MAPK8TBK1MAPK9JAK2 | |
| SCHEMBL3751056 | 0.84 | MAPK10 (0.56) | MAPK10MAPK8TBK1MAPK9JAK2 | |
| SCHEMBL3764854 | 0.84 | MAPK10 (0.61) | MAPK10MAPK8TBK1MAPK9JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200436-B1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2015-01-21 | — | — | EP | disclosed |