Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.81 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.81 |
| ▸ | CLK1 | P49759 | 10/20 | 0.81 |
| ▸ | DYRK1B | Q9Y463 | 9/20 | 0.81 |
| ▸ | CLK2 | P49760 | 8/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | CLK3 | P49761 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753237 | 0.83 | CLK1 (0.66) | CLK4DYRK1ACLK1DYRK1BCLK2 | |
| SCHEMBL3753054 | 0.83 | CLK1 (0.66) | CLK4DYRK1ACLK1DYRK1BCLK2 | |
| SCHEMBL3751635 | 0.82 | CLK4 (0.71) | CLK4DYRK1ACLK1DYRK1BCLK2 | |
| SCHEMBL6981394 | 0.81 | CLK1 (0.69) | CLK4DYRK1ACLK1DYRK1BCLK2 | |
| SCHEMBL3753229 | 0.80 | CLK1 (0.69) | CLK4DYRK1ACLK1DYRK1BCLK2 | |
| SCHEMBL14423371 | 0.78 | KDM4E (0.55) | CLK4DYRK1ACLK1DYRK1BCLK2 | |
| SCHEMBL14254224 | 0.78 | CLK1 (0.72) | CLK4DYRK1ACLK1DYRK1BCLK2 | |
| SCHEMBL15533939 | 0.78 | CLK1 (1.00) | CLK4DYRK1ACLK1DYRK1BCLK2 | |
| SCHEMBL14423352 | 0.77 | DYRK1A (0.50) | CLK4DYRK1ACLK1DYRK1BCLK2 | |
| SCHEMBL14021573 | 0.77 | HTT (0.56) | CLK4DYRK1ACLK1DYRK1BCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200436-B1 | SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2015-01-21 | — | — | EP | disclosed |